Beilstein J. Org. Chem.2021,17, 2932–2938, doi:10.3762/bjoc.17.202
-formyl amide products have unique properties and reactivity, but are difficult or impossible to access by traditional synthetic approaches.
Keywords: formyl peptide; nitroaryl compound; nitroso compound; olefincleavage; photocleavage; Findings
The photochemistry of nitroaromatic functional groups has
then account for the isolation of the acetylated analogue 9.
The photochemical pathway described here represents a formal oxidative olefincleavage of vinylogous nitroaryl-modified amides and ethers. The pathway adds to the diversity of photochemical pathways known for 2-nitrophenyl systems, and the
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Graphical Abstract
Figure 1:
Uncaging of peptide backbone N–H bonds from Chan–Lam-type modification.